Blood type influences lung cancer mortality
Wednesday, June 27, 2007
NEW YORK (Reuters Health) - An analysis of data from a Danish study shows that inflammation factors are stronger predictors of lung cancer mortality in individuals with blood type O than those with other blood types.
The inflammatory response is thought to play a key role in the development of lung cancer and there is evidence that this response is influenced by a person's ABO type, according to the report in the European Respiratory Journal.
The most important blood types are in the ABO group, which can be typed for all humans and many other primates. There are four principal types: A, B, AB, and O. The combination of these four components determines an individual's type.
To investigate the impact of ABO type on lung cancer risk factors, Dr. P. Suadicani and colleagues at Bispebjerg University Hospital assessed the long-term outcomes of 3346 men enrolled in the Copenhagen Male Study. The average age was 63 years and the subjects were followed for 16 years.
During follow-up, 170 subjects died from lung cancer, including 84 (5.9 percent) with type O, 70 (4.9 percent) with type A and 16 (3.2 percent) with type B/AB.
In men with type O blood, cumulative tobacco use, high salt intake, long-term occupational dust exposure, high fat intake, alcohol consumption, and older age were all risk factors for lung cancer mortality. High salt levels in the diet, long-term occupational dust exposure, and heavy alcohol use (more than 10 wine drinks per week) each increased the risk of lung cancer death by more than twofold.
By contrast, in men with blood type A, only total tobacco use and increasing age were linked to lung cancer death. With type B/AB, increasing age and possibly long-term occupational dust exposure were risk factors for lung cancer mortality.
These findings suggest that the ABO type strongly affects whether various lifestyle factors impact the risk of lung cancer mortality, the authors conclude.
SOURCE: European Respiratory Journal, June 27, 2007.
血型影响肺癌死亡率
Blood type influences lung cancer mortality
Wednesday, June 27, 2007
血型影响肺癌死亡率
星期三，2007年6月27日
NEW YORK (Reuters Health) - An analysis of data from a Danish study shows that inflammation factors are stronger predictors of lung cancer mortality in individuals with blood type O than those with other blood types.
纽约（路透通讯社健康专栏）—一项来自丹麦的研究资料分析显示，发炎因素是肺癌死亡率发生最强有力的预兆，这种症状发生在O型血的人要比其他类型血的人多。
The inflammatory response is thought to play a key role in the development of lung cancer and there is evidence that this response is influenced by a person's ABO type, according to the report in the European Respiratory Journal.
炎症免疫应答被认为在肺癌的发展中起着关键作用，有证据表明，这种应答受血型的影响，根据欧洲呼吸系统杂志报道。
The most important blood types are in the ABO group, which can be typed for all humans and many other primates. There are four principal types: A, B, AB, and O. The combination of these four components determines an individual's type.
最重要的血型是ABO类型划分，它存在于所有人类和许多其他灵长类中。有4种主要的类型：A,B,AB,和O型。这4种的组合决定每个人的血型。
To investigate the impact of ABO type on lung cancer risk factors, Dr. P. Suadicani and colleagues at Bispebjerg University Hospital assessed the long-term outcomes of 3346 men enrolled in the Copenhagen Male Study. The average age was 63 years and the subjects were followed for 16 years.
为了去研究ABO血型对癌症危险度因子的影响，P. Suadicani博士和他在Bispebjerg大学医院的同事评估了在哥本哈根男子研究中心登记的3346个男性的长期的研究结果。受试者平均年龄是63岁并且要连续跟踪16年。
During follow-up, 170 subjects died from lung cancer, including 84 (5.9 percent) with type O, 70 (4.9 percent) with type A and 16 (3.2 percent) with type B/AB.
在接下来的研究中，170例受试者死于肺癌，其中包括84（5.9℅）个O型血的人，70（4.9℅）个A型血的人和16（3.2℅）个B/AB类型血的人。
In men with type O blood, cumulative tobacco use, high salt intake, long-term occupational dust exposure, high fat intake, alcohol consumption, and older age were all risk factors for lung cancer mortality. High salt levels in the diet, long-term occupational dust exposure, and heavy alcohol use (more than 10 wine drinks per week) each increased the risk of lung cancer death by more than twofold.
在O型血的人中考察的癌症危险度因子有，长期吸烟，食盐量过高，在职业中长期接触粉尘，高脂肪摄入，酗酒，和年老等。其中食盐量过高，在职业中长期接触粉尘和酗酒（每周超过10次以上）是最重要的肺癌死亡因素。
By contrast, in men with blood type A, only total tobacco use and increasing age were linked to lung cancer death. With type B/AB, increasing age and possibly long-term occupational dust exposure were risk factors for lung cancer mortality.
与之相对照的是，在A型血的人中，仅仅长期吸烟和年龄增加和肺癌死亡相关。在B/AB型血的人中，年龄增加和在职业中长期接触粉尘是肺癌死亡率最关键的因素。
These findings suggest that the ABO type strongly affects whether various lifestyle factors impact the risk of lung cancer mortality, the authors conclude.
这些发现认为，对ABO型血的人来说，是否说明不同的生活方式对肺癌死亡率有重要的影响，作者最后作出结论说。
SOURCE: European Respiratory Journal, June 27, 2007.
来源：欧洲呼吸系统杂志，2007，6，27
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