[2007.3.27][转贴][APTX青山病院]蓝莓含有的一种化学成分可能有助于预防结肠癌

wangyuankai

title: Blueberries Contain Chemical That May Help Prevent Colon Cancer

Science Daily — A compound found in blueberries shows promise of preventing colon cancer in animals, according to a joint study by scientists at Rutgers University and the U.S. Department of Agriculture. The compound, pterostilbene, is a potent antioxidant that could be developed into a pill with the potential for fewer side effects than some commercial drugs that are currently used to prevent the disease. Colon cancer is considered the second leading cause of cancer death in the United States, the researchers say.
While recent studies have identified a growing number of antioxidants in fruits, vegetables and whole grains that show potential for fighting colon cancer, this is believed to be the first study to demonstrate the cancer-fighting potential of pterostilbene against the disease, the scientists say. Their findings were described at the 233rd national meeting of the American Chemical Society. March is National Colorectal Cancer Awareness Month.
"This study underscores the need to include more berries in the diet, especially blueberries," says study leader Bandaru Reddy, Ph.D., a professor in the Department of Chemical Biology at Rutgers in Piscataway, N.J. Although the blueberry compound won't cure colon cancer, it represents a potential new and attractive strategy for preventing the disease naturally, says Reddy, a leading expert on nutritional factors that influence colon cancer development.
Along with scientists Nanjoo Suh, also of Rutgers, and Agnes Rimando of the USDA's Agricultural Research Service (ARS), Reddy and his associates conducted a small pilot study to determine the effect of pterostilbene on colon cancer. The study included 18 rats that were given a compound (azoxymethane) to induce colon cancer in a manner similar to human colon cancer development. Nine of the animals were then placed on a balanced daily diet, while the other nine were given the same diet supplemented with pterostilbene (at a level of 40 parts per million).
At the end of an eight-week study period, the rats that were fed pterostilbene showed 57 percent fewer pre-cancerous lesions in their colon in comparison to the control group, Reddy and his associates say. Pterostilbene also reduced colonic cell proliferation and inhibited certain genes involved in inflammation, both of which are considered colon cancer risk factors, the researchers say.
Although researchers still do not know the exact cause of colon cancer, the disease has been linked to a high intake of saturated fats and calories, particularly in Western diets. Pterostilbene may be able to reverse this process, possibly by lowering lipids, Reddy says. He cites a recent study by co-author Agnes Rimando, a research chemist at the USDA-ARS, who demonstrated in cell and animal studies that pterostilbene is capable of lowering cholesterol levels. In a related paper also being presented at the ACS national meeting, Rimando demonstrated that blueberries, particularly their skins, can lower cholesterol when fed to animals (see AGFD 038 reference below). More studies on the mechanism of action of pterostilbene are needed, the researchers note.
Reddy recently demonstrated that certain COX-2 inhibitors, anti-inflammatory drugs that are used for pain and arthritis, were capable of preventing colon cancer in animals. But studies by others have shown that COX-2 inhibitors also can increase the risk of heart attacks and strokes when used in high doses. Combining pterostilbene with these COX-2 drugs could allow them to be used in lower doses, reducing their risk of adverse side effects, Reddy says. More studies are needed to determine the compound's efficacy and potential for toxicity, he notes.
Pterostilbene is an antioxidant that is similar to resveratrol, an antioxidant identified in grapes and red wine that also is recognized for its anticancer properties. Pterostilbene also is found in grapes, but it is more abundant in blueberries, the researchers say.
In studies by other researchers, blueberries also have shown promise for protecting against memory loss and heart disease. In general, a diet rich in fruits, vegetables and grain is recommended by health experts for the prevention of colon cancer. Funding for this study was provided by the National Cancer Institute.





Blueberries Contain Chemical That May Help Prevent Colon Cancer
标题：蓝莓含有的一种化学成分可能有助于预防结肠癌
Science Daily 科学日报
A compound found in blueberries shows promise of preventing colon cancer in animals, according to a joint study by scientists at Rutgers University and the U.S. Department of Agriculture. The compound, pterostilbene, is a potent antioxidant that could be developed into a pill with the potential for fewer side effects than some commercial drugs that are currently used to prevent the disease. Colon cancer is considered the second leading cause of cancer death in the United States, the researchers say.
据Rutgers大学和美国农业部的一项联合研究表明，在蓝莓中发现的一种化合物在动物身上显示出预防结肠癌的前景。这种被称为紫檀芪的化合物是一种有效的抗氧化物质，将有可能成为预防结肠癌的药物，与当前预防结肠癌的一些常用的商品化药物相比，副作用可能更少。研究人员说，结肠癌已成为美国癌症患者的第二大死因。
While recent studies have identified a growing number of antioxidants in fruits, vegetables and whole grains that show potential for fighting colon cancer, this is believed to be the first study to demonstrate the cancer-fighting potential of pterostilbene against the disease, the scientists say. Their findings were described at the 233rd national meeting of the American Chemical Society. March is National Colorectal Cancer Awareness Month.
近来很多研究均证实，在水果、蔬菜及整体五谷中存在很多抗氧化物质，这些物质均具有潜在的抗结肠癌能力；但是，科学家们认为该研究首次证实了紫檀芪的抗结肠癌的潜能。研究结果将在第233界美国化学学会年会上披露。三月是国家大肠直肠癌认知月。
"This study underscores the need to include more berries in the diet, especially blueberries," says study leader Bandaru Reddy, Ph.D., a professor in the Department of Chemical Biology at Rutgers in Piscataway, N.J. Although the blueberry compound won't cure colon cancer, it represents a potential new and attractive strategy for preventing the disease naturally, says Reddy, a leading expert on nutritional factors that influence colon cancer development.
Along with scientists Nanjoo Suh, also of Rutgers, and Agnes Rimando of the USDA's Agricultural Research Service (ARS), Reddy and his associates conducted a small pilot study to determine the effect of pterostilbene on colon cancer. The study included 18 rats that were given a compound (azoxymethane) to induce colon cancer in a manner similar to human colon cancer development. Nine of the animals were then placed on a balanced daily diet, while the other nine were given the same diet supplemented with pterostilbene (at a level of 40 parts per million).
位于新泽西州Piscataway的Rutgers大学的化学生物系的教授，该研究的领头人Bandaru Reddy博士说，“这项研究强调了日常饮食需要含有更多的浆果类食物，特别是蓝莓。Reddy是研究营养因素对结肠癌发展影响方面的权威，他认为，虽然蓝莓中的这种物质无法治愈结肠癌，但是它代表一种新的有吸引力的预防结肠癌的自然策略。Reddy及其助手与同为Rutgers大学的科学家Nanjoo Suh和来自美国农业部农业研究所的Agnes Rimando一起进行了一个小型的前瞻性研究，以确定紫檀芪的抗结肠癌效果。该研究纳入18只大鼠为研究对象，研究人员给这些大鼠注射氧化偶氮甲烷，诱导大鼠产生与人类类似的结肠癌。然后，其中的9只大鼠每日给予均衡饮食喂养，另外的大鼠在均衡饮食的基础上添加40ppm的紫檀芪。
At the end of an eight-week study period, the rats that were fed pterostilbene showed 57 percent fewer pre-cancerous lesions in their colon in comparison to the control group, Reddy and his associates say. Pterostilbene also reduced colonic cell proliferation and inhibited certain genes involved in inflammation, both of which are considered colon cancer risk factors, the researchers say.
Reddy及其同事说，在8周的研究期限结束后，与对照组相比，给予紫檀芪喂养的大鼠的结肠癌前病变数减少57％。此外，紫檀芪能减少结肠细胞的增殖，抑制炎症因子基因表达，而结肠细胞增殖及炎症因子基因表达均为结肠癌的危险因素。
Although researchers still do not know the exact cause of colon cancer, the disease has been linked to a high intake of saturated fats and calories, particularly in Western diets. Pterostilbene may be able to reverse this process, possibly by lowering lipids, Reddy says. He cites a recent study by co-author Agnes Rimando, a research chemist at the USDA-ARS, who demonstrated in cell and animal studies that pterostilbene is capable of lowering cholesterol levels. In a related paper also being presented at the ACS national meeting, Rimando demonstrated that blueberries, particularly their skins, can lower cholesterol when fed to animals (see AGFD 038 reference below). More studies on the mechanism of action of pterostilbene are needed, the researchers note.
虽然结肠癌的确切病因仍不清楚，但该病已经被证实与西方饮食中大量摄入饱和脂肪、卡路里有关。Reddy认为，紫檀芪可能通过降脂从而逆转癌变，他引用了他的合著者Agnes Rimando一项近期的研究，gnes Rimando是美国农业部农业研究所的化学家，他在细胞、动物实验研究中证实紫檀芪具有降脂功能。Rimando在另外一个研究中证实喂食蓝莓特别是蓝莓的皮能够降低实验动物的胆固醇水平，该研究论文将在ACS年会上公布。研究人员指出，需要更多的研究以阐明紫檀芪的作用机制。
Reddy recently demonstrated that certain COX-2 inhibitors, anti-inflammatory drugs that are used for pain and arthritis, were capable of preventing colon cancer in animals. But studies by others have shown that COX-2 inhibitors also can increase the risk of heart attacks and strokes when used in high doses. Combining pterostilbene with these COX-2 drugs could allow them to be used in lower doses, reducing their risk of adverse side effects, Reddy says. More studies are needed to determine the compound's efficacy and potential for toxicity, he notes.
Reddy近来的研究证实，在动物实验中，某些COX-2抑制剂、用来镇痛及治疗关节炎的抗炎药物能预防结肠癌。但是其他的一些研究表明COX-2抑制剂会增加心脏病、中风的发生风险。Reddy说，COX-2抑制剂与紫檀芪联用则能减少用药剂量，减少药物的不良反应带来的危险。他指出，需要进行更多的研究以明确紫檀芪的疗效及其潜在的毒性。
Pterostilbene is an antioxidant that is similar to resveratrol, an antioxidant identified in grapes and red wine that also is recognized for its anticancer properties. Pterostilbene also is found in grapes, but it is more abundant in blueberries, the researchers say.
紫檀芪是一种与白藜芦醇类似的抗氧化剂，白藜芦醇存在于葡萄或红酒中，被认为具有抗癌功能。研究人员说，葡萄中也含有紫檀芪，但蓝莓中的含量更大。
In studies by other researchers, blueberries also have shown promise for protecting against memory loss and heart disease. In general, a diet rich in fruits, vegetables and grain is recommended by health experts for the prevention of colon cancer. Funding for this study was provided by the National Cancer Institute.
在其他的研究中，蓝莓还显示出防治记忆丧失及心脏病的前景。一般来说，健康专家推荐富含水果、蔬菜、谷物的饮食来预防结肠癌。
Note: This story has been adapted from a news release issued by American Chemical Society.
备注：该研究资金由国家癌症研究院赞助。






编译
标题：蓝莓含有的一种化学成分可能有助于预防结肠癌

来源：科学日报

据Rutgers大学和美国农业部的一项联合研究表明，在蓝莓中发现的一种化合物在动物身上显示出预防结肠癌的前景。这种被称为紫檀芪的化合物是一种有效的抗氧化物质，将有可能被成为预防结肠癌的药物，与当前预防结肠癌的一些常用的商品化药物相比，副作用可能更少。研究人员说，结肠癌已成为美国癌症患者的第二大死因。

近来很多研究均证实，在水果、蔬菜及整体五谷中存在很多抗氧化物质，这些物质均具有潜在的抗结肠癌能力；但是，科学家们认为该研究首次证实了紫檀芪的抗结肠癌的潜能。研究结果将在第233界美国化学学会年会上披露。三月是国家大肠直肠癌认知月。

位于新泽西州Piscataway的Rutgers大学的化学生物系的教授，该研究的领头人Bandaru Reddy博士说，“这项研究强调了日常饮食需要含有更多的浆果类食物，特别是蓝莓。Reddy是研究营养因素对结肠癌发展影响方面的权威，他认为，虽然蓝莓中的这种物质无法治愈结肠癌，但是它代表一种新的有吸引力的预防结肠癌的自然策略。Reddy及其助手与同为Rutgers大学的科学家Nanjoo Suh和来自美国农业部农业研究所的Agnes Rimando一起进行了一个小型的前瞻性研究，以确定紫檀芪的抗结肠癌效果。该研究纳入18只大鼠为研究对象，研究人员给这些大鼠注射氧化偶氮甲烷，诱导大鼠产生与人类类似的结肠癌。然后，其中的9只大鼠每日给予均衡饮食喂养，另外的大鼠在均衡饮食的基础上添加40ppm的紫檀芪。

Reddy及其同事说，在8周的研究期限结束后，与对照组相比，给予紫檀芪喂养的大鼠的结肠癌前病变数减少57％。此外，紫檀芪能减少结肠细胞的增殖，抑制炎症因子基因表达，而结肠细胞增殖及炎症因子基因表达均为结肠癌的危险因素。

虽然结肠癌的确切病因仍不清楚，但该病已经被证实与西方饮食中大量摄入饱和脂肪、卡路里有关。Reddy认为，紫檀芪可能通过降脂从而逆转癌变，他引用了他的合著者Agnes Rimando一项近期的研究，gnes Rimando是美国农业部农业研究所的化学家，他在细胞、动物实验研究中证实紫檀芪具有降脂功能。Rimando在另外一个研究中证实喂食蓝莓特别是蓝莓的皮能够降低实验动物的胆固醇水平，该研究论文将在ACS年会上公布。研究人员指出，需要更多的研究以阐明紫檀芪的作用机制。

Reddy近来的研究证实，在动物实验中，某些COX-2抑制剂、用来镇痛及治疗关节炎的抗炎药物能预防结肠癌。但是其他的一些研究表明COX-2抑制剂会增加心脏病、中风的发生风险。Reddy说，COX-2抑制剂与紫檀芪联用则能减少用药剂量，减少药物的不良反应带来的危险。他指出，需要进行更多的研究以明确紫檀芪的疗效及其潜在的毒性。

紫檀芪是一种与白藜芦醇类似的抗氧化剂，白藜芦醇存在于葡萄或红酒中，被认为具有抗癌功能。研究人员说，葡萄中也含有紫檀芪，但蓝莓中的含量更大。

在其他的研究中，蓝莓还显示出防治记忆丧失及心脏病的前景。一般来说，健康专家推荐富含水果、蔬菜、谷物的饮食来预防结肠癌。该研究资金由国家癌症研究院赞助。

补充：根据google提供的搜索结果，发现除了蓝莓、葡萄之外，药用植物紫檀及血竭制品中也含有紫檀芪；此外，紫檀芪还具有抗真菌的功能。
目前我们国内对紫檀芪的研究较少。

延伸阅读：
1.(药用)紫檀[U]http://luxflower.net/hhyaoyong/show.asp?id=40[/U]

2.多吃色彩鲜艳的水果可防治老年性疾病[U]http://www.ebiotrade.com/newsf/2004-8/2004825153415.htm[/U]

3.反相高效液相色谱法测定龙血竭中紫檀芪的含量
[U]http://ckrd143.cnki.net/grid20/detail.aspx?QueryID=5&CurRec=2[/U]

noir

我好像只吃过蓝莓果酱……

风之翼

我也是经常吃蓝莓酸奶~