[破事水水] [2007.8.11][转贴][APTX青山病院]慢性失眠与大脑结构

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发表于 2007-8-11 14:50:10 |只看该作者 |倒序浏览

Chronic Insomniaand MRI-Measured Hippocampal Volumes: A Pilot Study

Dieter Riemann, PhD1; Ulrich Voderholzer, MD1; KaiSpiegelhalder, Dipl Psych1; Magdolna Hornyak, MD1; Daniel J. Buysse, MD2;Christoph Nissen, MD1,2; Jürgen Hennig, PhD3; Michael L. Perlis, PhD4; LudgerTebartz van Elst, MD1; Bernd Feige, PhD1

1Department of Psychiatry and Psychotherapy, FreiburgUniversity Medical Center, Freiburg, Germany; 2Department of Psychiatry,University of Pittsburgh School of Medicine, Pittsburgh, PA; 3Department ofRadiology, Freiburg University Medical Center, Freiburg, Germany; 4Departmentof Psychiatry of the University of Rochester, Rochester, NY

Study Objectives:

Morphometric analysis of magnetic resonance imagingbrain scans was used to investigate possible neuroanatomic differences betweenpatients with primary insomnia compared to good sleepers.

Design:

MRI images (1.5 Tesla) of the brain were obtained frominsomnia patients and good sleepers. MRI scans were analyzed bilaterally bymanual morphometry for different brain areas including hippocampus, amygdala,anterior cingulate, orbitofron-tal and dorsolateral prefrontal cortex.

Setting:

University Hospital Sleep Center and Radiology Department Participants: 8 unmedicatedphysician-referred patients with chronic primary insomnia (3 males, 5 females;48.4 + 16.3 years) and 8 good sleepers matched for age, sex, body mass index,and education.

Interventions: N/A

Measurements and Results:

Patients with primary insomnia demonstratedsignificantly reduced hippocampal volumes bilaterally compared to the goodsleepers. None of the other regions of interest analyzed revealed differencesbetween the 2 groups.

Conclusions:

These pilot data raise the possibility that chronicinsomnia is associated with alterations in brain structure. Replication of thefindings in larger samples is needed to confirm the validity of the data. Theintegration of structural, neuropsychological, neuroendocrine andpolysomnographic studies is necessary to further assess the relationshipsbetween insomnia and brain function and structure.

慢性失眠与磁共振成像测量海马体积:试点研究
研究目标: 应用磁共振成象（MRI）大脑扫描形态测定分析，探讨原发性失眠患者与睡眠良好者之间神经解剖学差异。
设计: MRI( 1.5T)图像来自失眠患者及睡眠良好者，根据形态测定指南，MRI扫描分析两侧脑的不同部位，包括海马、杏仁核、扣带、眶额及背侧前额叶皮层。
设定: 大学附属医院睡眠中心和放射科参与者:医师提交的未服药慢性原发性失眠患者8例( 3男5女; 48.4 + 16.3岁)和8位年龄、性别、身体质量指数、教育程度匹配的睡眠良好者。
干预: N/A
测量与结果:
与睡眠良好者相比，原发性失眠患者双侧海马体积显著减少，其他分析部位两组无明显差异。
结论:
这些试验数据提示，慢性失眠可能与大脑结构改变有关。需要大样本的研究重现这一研究结果来证实结果的可靠性。有必要进行包括神经心理、神经内分泌、多功能睡眠记录仪在内的综合研究，以进一步评估失眠与脑功能及结构的关系。

一个有趣的研究和有趣的结果